Anodyne is the fourth and final studio album by alternative country band Uncle Tupelo, released on October 5, 1993. The recording of the album was preceded by the departure of the original drummer Mike Heidorn and the addition of three new band members: bassist John Stirratt, drummer Ken Coomer, and multi-instrumentalist Max Johnston. The band signed with Sire Records shortly before recording the album; Anodyne was Uncle Tupelo's only major label release until 89/93: An Anthology in 2002.
Recorded in Austin, Texas, Anodyne featured a split in songwriting credits between singers Jay Farrar and Jeff Tweedy, plus a cover version of the Doug Sahm song "Give Back the Key to My Heart", with Sahm on vocals. The lyrical themes were influenced by country music and—more than their preceding releases—touched on interpersonal relationships. After two promotional tours for the album, tensions between Farrar and Tweedy culminated in the breakup of Uncle Tupelo. Well-received upon its initial release, Anodyne was re-mastered and re-released in 2003 by Rhino Entertainment including five bonus tracks.
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